Early View Articles articles

Mapping parahippocampal systems for recognition and recency memory in the absence of the rat hippocampus

by L. Kinnavane, E. Amin, M. Horne, J. P. Aggleton Abstract The present study examined immediate-early gene expression in the perirhinal cortex of rats with hippocampal lesions. The goal was to test those models of recognition memory which assume that the perirhinal cortex can function independently of the hippocampus. The c-fos gene was targeted, as […]

The predictability of frequency-altered auditory feedback changes the weighting of feedback and feedforward input for speech motor control

by Nichole E. Scheerer, Jeffery A. Jones Abstract Speech production requires the combined effort of a feedback control system driven by sensory feedback, and a feedforward control system driven by internal models. However, the factors that dictate the relative weighting of these feedback and feedforward control systems are unclear. In this event-related potential (ERP) study, […]

Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood

by Vincent Bombail, Wei Qing, Karen E. Chapman, Megan C. Holmes Abstract The 5-hydroxytryptamine2C (5-HT)2C receptor is widely implicated in the aetiology of affective and eating disorders as well as regulation of the hypothalamo-pituitary-adrenal axis. Signalling through this receptor is regulated by A-to-I RNA editing, affecting three amino acids in the protein sequence, with unedited […]

High-frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors

by Yijing Xie, Tjitske Heida, Jan Stegenga, Yan Zhao, Andreas Moser, Volker Tronnier, Thomas J. Feuerstein, Ulrich G. Hofmann Abstract The nucleus accumbens is selected as a surgical target in deep brain stimulation for treating refractory obsessive-compulsive disorder (OCD). One of the therapeutic benefits of this procedure is that the abnormal hyper-functioning prefrontal cortex of […]

In search of the holy grail of fly motion vision

by Alexander Borst Abstract Detecting the direction of image motion is important for visual navigation as well as predator, prey and mate detection and, thus, essential for the survival of all animals that have eyes. However, the direction of motion is not explicitly represented at the level of the photoreceptors: it rather needs to be […]

Neurophysiological evidence for the presence of cannabinoid CB1 receptors in the laterodorsal tegmental nucleus

by Neeraj Soni, Shankha Satpathy, Kristi A. Kohlmeier Abstract Marijuana, which acts within the endocannabinoid (eCB) system as an agonist of the cannabinoid type 1 receptor (CB1R), exhibits addictive properties and has powerful actions on the state of arousal of an organism. The laterodorsal tegmental nucleus (LDT), as a component of the reticular activating system, is […]

Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

by Emanuele Brai, Swananda Marathe, Lorena Zentilin, Mauro Giacca, Johannes Nimpf, Robert Kretz, Alessandra Scotti, Lavinia Alberi Abstract Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory […]

Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal

by Hao Li, Jamie L. Scholl, Wenyu Tu, James E. Hassell, Michael J. Watt, Gina L. Forster, Kenneth J. Renner Abstract Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala […]

Sensory-specific modulation of adult neurogenesis in sensory structures is associated with the type of stem cell present in the neurogenic niche of the zebrafish brain

by Benjamin W. Lindsey, Sabrina Di Donato, Jan Kaslin, Vincent Tropepe Abstract Teleost fishes retain populations of adult stem/progenitor cells within multiple primary sensory processing structures of the mature brain. Though it has commonly been thought that their ability to give rise to adult-born neurons is mainly associated with continuous growth throughout life, whether a […]