Early View Articles articles

RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions

by Andrew R. Chandna, Manoj Nair, Christine Chang, Paul R. Pennington, Yasuhiko Yamamoto, Darrell D. Mousseau, Verónica A. Campanucci Abstract Autonomic dysfunction is a serious complication of diabetes and can lead to cardiovascular abnormalities and premature death. It was recently proposed that autonomic dysfunction is triggered by oxidation-mediated inactivation of neuronal nicotinic acetylcholine receptors (nAChRs), […]

Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons

by Vivien Zell, Pierre-Éric Juif, Ulrike Hanesch, Pierrick Poisbeau, Fernand Anton, Pascal Darbon Abstract Corticosterone (CORT) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic–pituitary–adrenal axis. Circulating CORT can enter the central nervous system and be reduced to neuroactive 3α5α-reduced steroids, which modulate GABAA receptors. In the dorsal spinal cord, GABAergic […]

Preferential assembly of heteromeric small conductance calcium-activated potassium channels

by Timothy W. Church, Kate L. Weatherall, Sonia A. L. Corrêa, David L. Prole, Jon T. Brown, Neil V. Marrion Abstract The activation of small conductance calcium-dependent (SK) channels regulates membrane excitability by causing membrane hyperpolarization. Three subtypes (SK1-3) have been cloned, with each subtype expressed within the nervous system. The locations of channel subunits […]

Inhibition in the lateral septum increases sucrose intake and decreases anorectic effects of stress

by Arojit Mitra, Christophe Lenglos, Elena Timofeeva Abstract Sucrose-overeating rats with decreased anorectic response to stress showed lower stress-induced activation of c-fos expression in the lateral septum (LS). The present study tested a hypothesis that neuronal inhibition in the LS is important for the development and maintenance of the sucrose-overeating phenotype. Sucrose overeating was developed […]

A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction

by Kalicharan Patra, David J. Lyons, Pavol Bauer, Markus M. Hilscher, Swati Sharma, Richardson N. Leão, Klas Kullander Abstract The solute carrier and presynaptic vesicle protein solute carrier family 10 member 4, or vesicular aminergic-associated transporter (VAAT), was recently proven to have a modulatory role in central cholinergic signalling. It is currently unknown whether VAAT […]

Perineuronal nets affect parvalbumin expression in GABAergic neurons of the mouse hippocampus

by J. Yamada, T. Ohgomori, S. Jinno Abstract Recent studies have suggested that the perineuronal net (PNN), a specialised extracellular matrix structure, and parvalbumin (PV), an EF-hand calcium-binding protein, are involved in the regulation of plasticity of neural circuits. Here, we aimed to quantitatively estimate the relationship between the two plasticity regulators, PV and PNNs, […]

The glycoprotein Ten-m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice

by Heidi Tran, Atomu Sawatari, Catherine A. Leamey Abstract The striatum is the key input nucleus of the basal ganglia, and is implicated in motor control and learning. Despite the importance of striatal circuits, the mechanisms associated with their development are not well established. Previously, Ten-m3, a member of the Ten-m/teneurin/odz family of transmembrane glycoproteins, […]

Synapse formation changes the rules for desensitization of PKC translocation in Aplysia

by Carole A. Farah, Faisal Naqib, Daniel B. Weatherill, Christopher C. Pack, Wayne S. Sossin Abstract Protein kinase Cs (PKCs) are activated by translocating from the cytoplasm to the membrane. We have previously shown that serotonin-mediated translocation of PKC to the plasma membrane in Aplysia sensory neurons was subject to desensitization, a decrease in the […]

Neural correlates of object size and object location during grasping actions

by Simona Monaco, Anna Sedda, Cristiana Cavina-Pratesi, Jody C. Culham Abstract The visuo-motor channel hypothesis (Jeannerod, 1981) postulates that grasping movements consist of a grip and a transport component differing in their reliance on intrinsic vs. extrinsic object properties (e.g. size vs. location, respectively). While recent neuroimaging studies have revealed separate brain areas implicated in […]

Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner

by Andrzej Bialowas, Sylvain Rama, Mickaël Zbili, Vincenzo Marra, Laure Fronzaroli-Molinieres, Norbert Ankri, Edmond Carlier, Dominique Debanne Abstract Synaptic transmission usually depends on action potentials (APs) in an all-or-none (digital) fashion. Recent studies indicate, however, that subthreshold presynaptic depolarization may facilitate spike-evoked transmission, thus creating an analog modulation of spike-evoked synaptic transmission, also called analog–digital […]