Early View Articles articles

Modulation of neuronal activity by reward identity in the monkey subthalamic nucleus

by Juan-Francisco Espinosa-Parrilla, Christelle Baunez, Paul Apicella Abstract The subthalamic nucleus (STN) has been argued to be an important component of reward-sensitive basal ganglia circuitry. This view is especially supported by the behavioral changes observed after STN inactivation which could reflect impairments in the motivational control of action. However, it is still unclear how the […]

Imaging learned fear circuitry in awake mice using fMRI

by Anjanette P Harris, Ross J Lennen, Ian Marshall, Maurits A Jansen, Cyril R Pernet, Nichola M Brydges, Ian C Duguid, Megan C Holmes Abstract Functional magnetic resonance imaging (fMRI) of learned behaviour in awake rodents provides the opportunity for translational preclinical studies into the influence of pharmacological and genetic manipulations on brain function. fMRI […]

Neural underpinnings of the “agent brain”: new evidence from transcranial direct current stimulation

by Annachiara Cavazzana, Barbara Penolazzi, Chiara Begliomini, Patrizia Silvia Bisiacchi Abstract Intentional Binding (IB) refers to the temporal compression between a voluntary action and its sensory effect, and it is considered an implicit measure of sense of agency (SoA), that is, the capacity of controlling one’s own actions. IB has been thoroughly studied from a […]

The classic P300 encodes a build-to-threshold decision variable

by Deirdre M Twomey, Peter R Murphy, Simon P Kelly, Redmond G O’Connell Abstract The P300 component of the human event-related potential has been the subject of intensive experimental investigation across a five-decade period, owing to its apparent relevance to a wide range of cognitive functions and its sensitivity to numerous brain disorders. Yet, its […]

Automatic representation of a visual stimulus relative to a background in the right precuneus

by Motoaki Uchimura, Tamami Nakano, Yusuke Morito, Hiroshi Ando, Shigeru Kitazawa Abstract Our brains represent the position of a visual stimulus egocentrically, in either retinal or craniotopic coordinates. In addition, recent behavioral studies have shown that the stimulus position is automatically represented allocentrically relative to a large frame in the background. Here, we investigated neural […]

Post-transcriptional regulation of dopamine D1 receptor expression in caudate-putamen of cocaine-sensitized mice

by Krishna E. Tobón, Jennifer E. Catuzzi, Samantha R. Cote, Adenike Sonaike, Eldo V. Kuzhikandathil Abstract The dopamine D1 receptor is centrally involved in mediating the effects of cocaine and is essential for cocaine-induced locomotor sensitization. Changes in D1 receptor expression has been reported in various models of cocaine addiction; however, the mechanisms that mediate […]

Methods for studying the zebrafish brain: past, present and future

by Cameron Wyatt, Ewelina M. Bartoszek, Emre Yaksi Abstract The zebrafish (Danio rerio) is one of the most promising new model organisms. The increasing popularity of this amazing small vertebrate is evident from the exponentially growing numbers of research articles, funded projects and new discoveries associated with the use of zebrafish for studying development, brain […]

Impairments in musical abilities reflected in the auditory brainstem: Evidence from congenital amusia

by Alexandre Lehmann, Erika Skoe, Patricia Moreau, Isabelle Peretz, Nina Kraus Abstract Congenital amusia is a neurogenetic condition, characterized by a deficit in music perception and production, not explained by hearing loss, brain damage or lack of exposure to music. Despite inferior musical performance, amusics exhibit normal auditory cortical responses, with abnormal neural correlates suggested […]

Sox4 participates in modulation of Schwann cell myelination

by Luca Bartesaghi, Estelle Arnaud Gouttenoire, Andrea Prunotto, Jean-Jacques Médard, Sven Bergmann, Roman Chrast Abstract In order to identify new regulators of Schwann cell myelination potentially playing a role in peripheral neural system pathologies, we analyzed gene expression profiling data from three mouse models of demyelinating neuropathies and from developing peripheral neural system. This analysis […]

Muscarinic modulation of TREK currents in mouse sympathetic superior cervical ganglion neurons

by P Rivas-Ramírez, A Cadaveira-Mosquera, JA Lamas, A Reboreda Abstract Muscarinic receptors play a key role in the control of neurotransmission in the autonomic ganglia, which has mainly been ascribed to the regulation of potassium M-currents and voltage-dependent calcium currents. Muscarinic agonists provoke depolarization of the membrane potential and a reduction in spike frequency adaptation […]