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Effects of the volatile anesthetic sevoflurane on tonic GABA currents in the mouse striatum during postnatal development

by Nozomi Ando, Yusuke Sugasawa, Ritsuko Inoue, Toshihiko Aosaki, Masami Miura, Kinya Nishimura Abstract The volatile anesthetic sevoflurane, which is widely used in pediatric surgery, has proposed effects on GABAA receptor-mediated extrasynaptic tonic inhibition. In the developing striatum, medium-sized spiny projection neurons have tonic GABA currents, which function in the excitatory/inhibitory balance and maturation of […]

The basolateral amygdala is necessary for negative prediction errors to enhance cue salience, but not to produce conditioned inhibition

by Guillem R. Esber, Peter C. Holland Abstract Behavioral evidence shows that prediction errors (PEs) not only drive associative learning, but also enhance the salience of predictive cues, making them better able to capture attention when they are next encountered. Research from our laboratory suggests that this latter consequence of PEs depends on a neural […]

The basolateral amygdala is necessary for negative prediction errors to enhance cue salience, but not to produce conditioned inhibition

by Guillem R. Esber, Peter C. Holland Abstract Behavioral evidence shows that prediction errors (PEs) not only drive associative learning, but also enhance the salience of predictive cues, making them better able to capture attention when they are next encountered. Research from our laboratory suggests that this latter consequence of PEs depends on a neural […]

Cannabinoid modulation of alpha2 adrenergic receptor function in rodent medial prefrontal cortex

by Alessandra M. Cathel, Beverly A. S. Reyes, Qin Wang, Jonathan Palma, Kenneth Mackie, Elisabeth J. Van Bockstaele, Lynn G. Kirby Abstract Endocannabinoids acting at the cannabinoid type 1 receptor (CB1R) are known to regulate attention, cognition and mood. Previous studies have shown that, in the rat medial prefrontal cortex (mPFC), CB1R agonists increase norepinephrine […]

Architecture and morphology of the human ventromedial prefrontal cortex

by Scott Mackey, Michael Petrides Abstract A previous report identified the location of comparable architectonic areas in the ventral frontal cortex of the human and macaque brains [S. Mackey & M. Petrides (2010) Eur. J. Neurosci., 32, 1940–1950]. The present article provides greater detail with regard to the definition of architectonic areas within the ventromedial […]

The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain

by Shun Hamada, Itone Ogawa, Miwako Yamasaki, Yuji Kiyama, Hidetoshi Kassai, Ayako M. Watabe, Kazuki Nakao, Atsu Aiba, Masahiko Watanabe, Toshiya Manabe Abstract The N-methyl-d-aspartate receptor (NMDAR) plays various physiological and pathological roles in neural development, synaptic plasticity and neuronal cell death. It is composed of two GluN1 and two GluN2 subunits and, in the […]

Activation of transient receptor potential vanilloid 2-expressing primary afferents stimulates synaptic transmission in the deep dorsal horn of the rat spinal cord and elicits mechanical hyperalgesia

by Hugues Petitjean, Sylvain Hugel, Florent Barthas, Yohann Bohren, Michel Barrot, Ipek Yalcin, Rémy Schlichter Abstract Probenecid, an agonist of transient receptor vanilloid (TRPV) type 2, was used to evaluate the effects of TRPV2 activation on excitatory and inhibitory synaptic transmission in the dorsal horn (DH) of the rat spinal cord and on nociceptive reflexes […]

Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation

by J. E. Orfila, K. Shimizu, A. K. Garske, G. Deng, J. Maylie, R. J. Traystman, N. Quillinan, J. P. Adelman, P. S. Herson Abstract Global cerebral ischemia following cardiac arrest and cardiopulmonary resuscitation (CA/CPR) causes injury to hippocampal CA1 pyramidal neurons and impairs cognition. Small conductance Ca2+-activated potassium channels type 2 (SK2), expressed in […]

Downregulation of Centaurin gamma1A increases synaptic transmission at Drosophila larval neuromuscular junctions

by Mizuho Homma, Shun Nagashima, Toshifumi Fukuda, Shigeru Yanagi, Hiroyoshi Miyakawa, Emiko Suzuki, Takako Morimoto Abstract Adequate regulation of synaptic transmission is critical for appropriate neural circuit functioning. Although a number of molecules involved in synaptic neurotransmission have been identified, the molecular mechanisms regulating neurotransmission are not fully understood. Here, we focused on Centaurin gamma1A […]

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