Early View Articles articles

LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation

by Marion Neuillé, Catherine W. Morgans, Yan Cao, Elise Orhan, Christelle Michiels, José-Alain Sahel, Isabelle Audo, Robert M. Duvoisin, Kirill A. Martemyanov, Christina Zeitz Abstract Mutations in LRIT3 lead to complete congenital stationary night blindness (cCSNB). The exact role of LRIT3 in ON-bipolar cell signaling cascade remains to be elucidated. Recently, we have characterized a […]

Layer-specific endocannabinoid-mediated LTD of GABAergic neurotransmission onto principal neurons in mouse visual cortex

by Wenjuan Sun, Laijian Wang, Shuo Li, Xiaoxiu Tie, Bin Jiang Abstract Visually induced endocannabinoid-mediated long-term depression of GABAergic neurotransmission (iLTD) mediates the maturation of GABAergic release in layer 2/3 of visual cortex. Here we examined whether the maturation of GABAergic transmission in other layers of visual cortex also requires endocannabinoids. The developmental plasticity of […]

Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease

by Christine Erie, Matthew Sacino, Lauren Houle, Michael Lu, Jianning Wei Abstract Huntington’s disease (HD) is a hereditary and devastating neurodegenerative disorder caused by a mutation in the huntingtin protein. Understanding the functions of normal and mutant huntingtin protein is the key to reveal the pathogenesis of HD and develop therapeutic targets. Huntingtin plays an […]

Dopamine transporter 3′ UTR VNTR modulates striatal function during working memory updating across the adult age span

by Fabio Sambataro, Jamie E. Podell, Vishnu P. Murty, Saumitra Das, Bhaskar Kolachana, Terry E. Goldberg, Daniel R. Weinberger, Venkata S. Mattay Abstract Dopamine modulation of striatal function is critical for executive functions such as working memory updating (UPD). The dopamine transporter (DAT) regulates striatal dopamine signaling via synaptic reuptake. A variable number of tandem […]

Effect of a single and repeated stress exposure on gene expression of catecholamine biosynthetic enzymes in brainstem catecholaminergic cell groups in rats

by Boris Mravec, Peter Vargovic, Peter Filipcik, Michal Novak, Richard Kvetnansky Abstract Brainstem catecholaminergic neurons significantly participate in the regulation of neuroendocrine system activity, particularly during stressful conditions. However, so far the precise quantitative characterization of basal and stress-induced changes in gene expression and protein levels of catecholaminergic biosynthetic enzymes in these neurons has been […]

Direct current stimulation over the human sensorimotor cortex modulates the brain's hemodynamic response to tactile stimulation

by Ye Wang, Ying Hao, Junhong Zhou, Peter J. Fried, Xiaoying Wang, Jue Zhang, Jing Fang, Alvaro Pascual-Leone, Brad Manor Abstract Tactile stimuli produce afferent signals that activate specific regions of the cerebral cortex. Noninvasive transcranial direct current stimulation (tDCS) effectively modulates cortical excitability. We therefore hypothesized that a single session of tDCS targeting the […]

Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav1.2)

by Panos Zanos, Shambhu Bhat, Chantelle E. Terrillion, Robert J. Smith, Leonardo H. Tonelli, Todd D. Gould Abstract Increased calcium influx through L-type voltage-gated calcium channels (L-VGCC) has been implicated in the neuronal dysfunction underlying age-related memory declines. In the present study we sought to test the specific role of Cacna1c (which encodes Cav1.2) in […]

Three-dimensional morphometric analysis of microglial changes in a mouse model of virus encephalitis: age and environmental influences

by Aline Andrade Sousa, Renata Rodrigues dos Reis, Camila Mendes Lima, Marcus Augusto Oliveira, Taiany Nogueira Fernandes, Giovanni Freitas Gomes, Daniel Guerreiro Diniz, Nara Morais Magalhães, Cristovam Guerreiro Diniz, Marcia Consentino Kronka Sosthenes, João Bento Torres Neto, José Antonio Picanço Diniz, Pedro Fernando da Costa Vasconcelos, Cristovam Wanderley Picanço Diniz Abstract Many RNA virus CNS […]

Cooperative processing in primary somatosensory cortex and posterior parietal cortex during tactile working memory

by Yixuan Ku, Di Zhao, Mark Bodner, Yong-Di Zhou Abstract In the present study, we investigated causal roles of both the primary somatosensory cortex (SI) and the posterior parietal cortex (PPC) in a tactile unimodal working memory (WM) task. Individual MRI-based single-pulse transcranial magnetic stimulation (spTMS) was applied respectively to left SI (ipsilateral to tactile […]