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Notch1 activity in the olfactory bulb is odour-dependent and contributes to olfactory behaviour

by Emanuele Brai, Swananda Marathe, Lorena Zentilin, Mauro Giacca, Johannes Nimpf, Robert Kretz, Alessandra Scotti, Lavinia Alberi Abstract Notch signalling plays an important role in synaptic plasticity, learning and memory functions in both Drosophila and rodents. In this paper, we report that this feature is not restricted to hippocampal networks but also involves the olfactory […]

Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal

by Hao Li, Jamie L. Scholl, Wenyu Tu, James E. Hassell, Michael J. Watt, Gina L. Forster, Kenneth J. Renner Abstract Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala […]

Sensory-specific modulation of adult neurogenesis in sensory structures is associated with the type of stem cell present in the neurogenic niche of the zebrafish brain

by Benjamin W. Lindsey, Sabrina Di Donato, Jan Kaslin, Vincent Tropepe Abstract Teleost fishes retain populations of adult stem/progenitor cells within multiple primary sensory processing structures of the mature brain. Though it has commonly been thought that their ability to give rise to adult-born neurons is mainly associated with continuous growth throughout life, whether a […]

Excessive disgust caused by brain lesions or temporary inactivations: mapping hotspots of the nucleus accumbens and ventral pallidum

by Chao-Yi Ho, Kent C. Berridge Abstract Disgust is a prototypical type of negative affect. In animal models of excessive disgust, only a few brain sites are known in which localized dysfunction (lesions or neural inactivations) can induce intense ‘disgust reactions’ (e.g. gapes) to a normally pleasant sensation such as sweetness. Here, we aimed to […]

GABAB modulation of dopamine release in the nucleus accumbens core

by Kimberley A. Pitman, Ernest Puil, Stephanie L. Borgland Abstract Modulation of the concentration of dopamine (DA) released from dopaminergic terminals in the nucleus accumbens (NAc) influences behaviours such as the motivation to obtain drugs of abuse. γ-Aminobutyric acid type B (GABAB) receptors are expressed throughout the mesolimbic circuit, including in the NAc, and baclofen, […]

Acoustical enrichment during early postnatal development changes response properties of inferior colliculus neurons in rats

by Zbyněk Bureš, Jolana Bartošová, Jiří Lindovský, Tetyana Chumak, Jiří Popelář, Josef Syka Abstract The structure and function of the auditory system may be influenced by acoustic stimulation, especially during the early postnatal period. This study explores the effects of an acoustically enriched environment applied during the third and fourth week of life on the […]

Impact of 5-Hz rTMS over the primary sensory cortex is related to white matter volume in individuals with chronic stroke

by Sonia M. Brodie, Michael R. Borich, Lara A. Boyd Abstract Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that may facilitate mechanisms of motor learning. In a recent single-blind, pseudo-randomized study, we showed that 5-Hz rTMS over ipsilesional primary somatosensory cortex followed by practice of a skilled motor task enhanced motor […]

Early-life-stress affects the homeostasis of glutamatergic synapses

by Syutaro Toya, Yusuke Takatsuru, Michifumi Kokubo, Izuki Amano, Noriaki Shimokawa, Noriyuki Koibuchi Abstract Early-life stress induces several neuropsychological disorders in adulthood, including depression. Such disorders may be induced by functional alteration of the glutamatergic system. However, their underlying mechanisms have not yet been fully clarified. Furthermore, the involvement of glucocorticoids, which are representative stress […]

Odour enrichment increases adult-born dopaminergic neurons in the mouse olfactory bulb

by Sara Bonzano, Serena Bovetti, Aldo Fasolo, Paolo Peretto, Silvia De Marchis Abstract The olfactory bulb (OB) is the first brain region involved in the processing of olfactory information. In adult mice, the OB is highly plastic, undergoing cellular/molecular dynamic changes that are modulated by sensory experience. Odour deprivation induces down-regulation of tyrosine hydroxylase (TH) […]

Complete protection from impending stroke following permanent middle cerebral artery occlusion in awake, behaving rats

by Christopher C. Lay, Ron D. Frostig Abstract Using a rodent model of ischemic stroke [permanent middle cerebral artery occlusion (pMCAO)], our laboratory has previously demonstrated that sensory-evoked cortical activation via mechanical single whisker stimulation treatment delivered under an anesthetized condition within 2 h of ischemic onset confers complete protection from impending infarct. There is a […]

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