Early View Articles articles

A role for solute carrier family 10 member 4, or vesicular aminergic-associated transporter, in structural remodelling and transmitter release at the mouse neuromuscular junction

by Kalicharan Patra, David J. Lyons, Pavol Bauer, Markus M. Hilscher, Swati Sharma, Richardson N. Leão, Klas Kullander Abstract The solute carrier and presynaptic vesicle protein solute carrier family 10 member 4, or vesicular aminergic-associated transporter (VAAT), was recently proven to have a modulatory role in central cholinergic signalling. It is currently unknown whether VAAT […]

Perineuronal nets affect parvalbumin expression in GABAergic neurons of the mouse hippocampus

by J. Yamada, T. Ohgomori, S. Jinno Abstract Recent studies have suggested that the perineuronal net (PNN), a specialised extracellular matrix structure, and parvalbumin (PV), an EF-hand calcium-binding protein, are involved in the regulation of plasticity of neural circuits. Here, we aimed to quantitatively estimate the relationship between the two plasticity regulators, PV and PNNs, […]

The glycoprotein Ten-m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice

by Heidi Tran, Atomu Sawatari, Catherine A. Leamey Abstract The striatum is the key input nucleus of the basal ganglia, and is implicated in motor control and learning. Despite the importance of striatal circuits, the mechanisms associated with their development are not well established. Previously, Ten-m3, a member of the Ten-m/teneurin/odz family of transmembrane glycoproteins, […]

Synapse formation changes the rules for desensitization of PKC translocation in Aplysia

by Carole A. Farah, Faisal Naqib, Daniel B. Weatherill, Christopher C. Pack, Wayne S. Sossin Abstract Protein kinase Cs (PKCs) are activated by translocating from the cytoplasm to the membrane. We have previously shown that serotonin-mediated translocation of PKC to the plasma membrane in Aplysia sensory neurons was subject to desensitization, a decrease in the […]

Neural correlates of object size and object location during grasping actions

by Simona Monaco, Anna Sedda, Cristiana Cavina-Pratesi, Jody C. Culham Abstract The visuo-motor channel hypothesis (Jeannerod, 1981) postulates that grasping movements consist of a grip and a transport component differing in their reliance on intrinsic vs. extrinsic object properties (e.g. size vs. location, respectively). While recent neuroimaging studies have revealed separate brain areas implicated in […]

Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner

by Andrzej Bialowas, Sylvain Rama, Mickaël Zbili, Vincenzo Marra, Laure Fronzaroli-Molinieres, Norbert Ankri, Edmond Carlier, Dominique Debanne Abstract Synaptic transmission usually depends on action potentials (APs) in an all-or-none (digital) fashion. Recent studies indicate, however, that subthreshold presynaptic depolarization may facilitate spike-evoked transmission, thus creating an analog modulation of spike-evoked synaptic transmission, also called analog–digital […]

Dopamine D2 receptors preferentially regulate the development of light responses of the inner retina

by Ning Tian, Hong-ping Xu, Ping Wang Abstract Retinal light responsiveness measured via electroretinography undergoes developmental modulation, and is thought to be critically regulated by both visual experience and dopamine. The primary goal of this study was to determine whether dopamine D2 receptors regulate the visual experience-dependent functional development of the retina. Accordingly, we recorded […]

Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice

by M. L. Mustroph, J. R. Merritt, A. L. Holloway, H. Pinardo, D. S. Miller, C. N. Kilby, P. Bucko, A. Wyer, J. S. Rhodes Abstract Recent evidence suggests that wheel running can abolish conditioned place preference (CPP) for cocaine in mice. Running significantly increases the number of new neurons in the hippocampus, and new […]