Early View Articles articles

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration

by Adrian M. Gomez, Wei-Lun Sun, Narasimha M. Midde, Steven B. Harrod, Jun Zhu Abstract Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condition (SC). The current study determined whether environmental enrichment differentially regulates […]

The thalamic reticular nucleus is activated by cortical spreading depression in freely moving rats: prevention by acute valproate administration

by Nermin Tepe, Aslı Filiz, Ergin Dilekoz, Didem Akcali, Yildirim Sara, Andrew Charles, Hayrunnisa Bolay Abstract This study investigated the effect of repetitive cortical spreading depression (CSD) on behaviour and the anatomical and physiological patterns of cellular activation of cortical and subcortical areas in awake, moving rats. Rat behaviours in response to repetitive CSD events […]

Sparing of orexin-A and orexin-B neurons in the hypothalamus and of orexin fibers in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated macaques

by Manale Bensaid, Dominique Tandé, Véronique Fabre, Patrick P. Michel, Etienne C. Hirsch, Chantal François Abstract Several studies conducted in patients with Parkinson’s disease have reported that the degeneration of substantia nigra dopaminergic neurons, which are essential for motor control, is associated with the loss of hypothalamic orexin neurons, which are involved in sleep regulation. […]

Functional connectivity in the resting-state motor networks influences the kinematic processes during motor sequence learning

by Laura Bonzano, Eleonora Palmaro, Roxana Teodorescu, Lazar Fleysher, Matilde Inglese, Marco Bove Abstract Neuroimaging studies support the involvement of the cerebello-cortical and striato-cortical motor loops in motor sequence learning. Here, we investigated whether the gain of motor sequence learning could depend on a-priori resting-state functional connectivity (rsFC) between motor areas and structures belonging to […]

Cortical indices of sound localization mature monotonically in early infancy

by Christopher Slugocki, Laurel J. Trainor Abstract In human neonates, orienting behavior in response to an off-midline sound source disappears around the first postnatal month, only to re-emerge at ~4 months. To date, it is unclear whether sound localization processes continue to operate between postnatal months 1 and 3. Here, we used an event-related potential, reflecting […]

Contribution of the motor system to the perception of reachable space: an fMRI study

by Angela Bartolo, Yann Coello, Martin G. Edwards, Samuel Delepoulle, Satoshi Endo, Alan M. Wing Abstract The present functional magnetic resonance imaging (fMRI) study investigates the neural correlates of reachability judgements. In a block design experiment, 14 healthy participants judged whether a visual target presented at different distances in a virtual environment display was reachable […]

Corticosterone and corticotropin-releasing factor acutely facilitate gamma oscillations in the hippocampus in vitro

by Gürsel Çalışkan, Steffen B. Schulz, David Gruber, Joachim Behr, Uwe Heinemann, Zoltan Gerevich Abstract Stressful experiences do not only cause peripheral changes in stress hormone levels, but also affect central structures such as the hippocampus, implicated in spatial orientation, stress evaluation, and learning and memory. It has been suggested that formation of memory traces […]

Greater sensitivity to novelty in rats is associated with increased motor impulsivity following repeated exposure to a stimulating environment: implications for the etiology of impulse control deficits

by Jacqueline-Marie N. Ferland, Fiona D. Zeeb, Katrina Yu, Sukhbir Kaur, Matthew D. Taves, Catharine A. Winstanley Abstract Heightened motor impulsivity and increased novelty-seeking commonly co-occur in psychiatric disorders, including drug addiction. However, the relationship between these two phenomena remains unclear. One-time tests of novelty sensitivity commonly used in preclinical experiments, such as the open-field […]

Spatial and temporal distribution of visual information coding in lateral prefrontal cortex

by Mikiko Kadohisa, Makoto Kusunoki, Philippe Petrov, Natasha Sigala, Mark J. Buckley, David Gaffan, John Duncan Abstract Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across […]

Interaural attention modulates outer hair cell function

by Sridhar Srinivasan, Andreas Keil, Kyle Stratis, Aaron F. Osborne, Colin Cerwonka, Jennifer Wong, Brenda L. Rieger, Valerie Polcz, David W. Smith Abstract Mounting evidence suggests that auditory attention tasks may modulate the sensitivity of the cochlea by way of the corticofugal and the medial olivocochlear (MOC) efferent pathways. Here, we studied the extent to […]