Early View Articles articles

The voice of the next generation

by Monica Di Luca, Barry J Everitt, Marian Joëls In May 2014, the Federation of European Neuroscience Societies (FENS) and the Kavli Foundation signed an agreement to establish a joint Network, celebrating and supporting the most talented mid-career neuroscientists in Europe. This Network, known as the FENS-Kavli Network of Excellence, is meant as a platform […]

Cortical inhibition of laser-pain and laser evoked potentials by non-nociceptive somatosensory input

by Elisa Testani, Domenica Le Pera, Claudio Del Percio, Roberto Miliucci, Alfredo Brancucci, Costanza Pazzaglia, Liala De Armas, Claudio Babiloni, Paolo Maria Rossini, Massimiliano Valeriani Abstract Although the inhibitory action that tactile stimuli can have on pain is well documented, the precise timing of the interaction between the painful and non-painful stimuli in the central […]

Functional evaluation of peripheral nerve regeneration and target reinnervation in animal models. A critical overview

by Xavier Navarro Abstract Peripheral nerve injuries usually lead to severe loss of motor, sensory and autonomic functions in the patients. Due to the complex requirements for adequate axonal regeneration, functional recovery is often poorly achieved. Experimental models are useful to investigate the mechanisms related to axonal regeneration and tissue reinnervation, and to test new […]

A correlation-based method for extracting subject-specific components and artifacts from group-fMRI data

by Siina Pamilo, Sanna Malinen, Jaakko Hotta, Mika Seppä Abstract We present a simple but effective correlation-based method (maxCorr) for extracting subject-specific components from group-fMRI data. The method finds signal components that correlate maximally with the data set of one subject and minimally with the data sets of the other subjects. We show that such […]

Lesions of the paraventricular nucleus of the thalamus differentially affect sign- and goal-tracking conditioned responses

by Joshua L. Haight, Kurt M. Fraser, Huda Akil, Shelly B. Flagel Abstract Recently evidence has emerged suggesting a role for the paraventricular nucleus of the thalamus (PVT) in the processing of reward-associated cues. However, the specific role of the PVT in these processes has yet to be elucidated. Here we use an animal model […]

Triptans Attenuate Circadian Responses to Light

by Priyoneel Basu, Naomi Ie, Adrienne L Wensel, Joelle D Baskerville, Victoria M Smith, Michael C Antle Abstract Daily exposure to light synchronizes the circadian clock, located in the suprachiasmatic nucleus (SCN), to external day/night cycles. These responses to light can be modified by serotonergic drugs, such as serotonin 5HT1B receptor agonists. Triptans are specific […]

Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing Autism Spectrum Disorders

by Christine T Wong, Joshua Wais, Dorota A Crawford Abstract The prevalence of Autism Spectrum Disorders (ASDs) has been on the rise over recent years. The presence of diverse subsets of candidate genes in each individual with an ASD and the vast variability of phenotypical differences suggest that the interference of an exogenous environmental component […]

Tuning of temporo-occipital activity by frontal oscillations during virtual mirror exposure causes erroneous self-recognition

by Andrea Serino, Anna Laura Sforza, Noriaki Kanayama, Michiel Elk, Mariia Kaliuzhna, Bruno Herbelin, Olaf Blanke Abstract Self-face recognition, a hallmark of self-awareness, depends on off-line stored information about one’s face and on-line multisensory-motor face-related cues. The brain mechanisms of how on-line sensory-motor processes affect off-line neural self-face representations are unknown. We used 3D virtual […]

Histamine resets the circadian clock in the suprachiasmatic nucleus through the H1R-CaV1.3-RyR pathway in the mouse

by Yoon Sik Kim, Young-Beom Kim, Woong Bin Kim, Bo-Eun Yoon, Feng-Yan Shen, Seung Won Lee, Tuck-Wah Soong, Hee-Chul Han, Christopher S. Colwell, C. Justin Lee, Yang In Kim Abstract Histamine, a neurotransmitter/neuromodulator implicated in the control of arousal state, exerts a potent phase-shifting effect on the circadian clock in the rodent suprachiasmatic nucleus (SCN). […]

Membrane turnover and receptor trafficking in regenerating axons

by Barbara Hausott, Lars Klimaschewski Abstract Peripheral axon regeneration requires surface-expanding membrane addition. The continuous incorporation of new membranes into the axolemma allows the pushing force of elongating microtubules to drive axonal growth cones forward. Hence, a constant supply of membranes and cytoskeletal building blocks is required, often for many weeks. In human peripheral nerves, […]