Early View Articles articles

Human Schwann-like cells from adipose-derived mesenchymal stem cells rapidly de-differentiate in the absence of stimulating media

by Alessandro Faroni, Richard JP Smith, Li Lu, Adam J Reid Abstract Finding a viable cell-based therapy to address peripheral nerve injury holds promise to enhance current suboptimal microsurgical approaches to peripheral nerve repair. Autologous nerve grafting is the current gold-standard for surgical repair of nerve gaps; however, this confers donor nerve morbidity to the […]

In vitro models for peripheral nerve regeneration

by S. Geuna, S. Raimondo, F. Fregnan, K. Haastert-Talini, C. Grothe Abstract The study of peripheral nerve repair and regeneration is particularly relevant in the light of the high clinical incidence of nerve lesions. Yet, clinical outcome after nerve lesions is often far from being satisfactory and the functional recovery is almost never complete. Therefore, […]

Known and unexpected constraints evoke different kinematic, muscle, and motor cortical neuron responses during locomotion

by Erik E. Stout, Mikhail G. Sirota, Irina N. Beloozerova Abstract During navigation through complex natural environments, people and animals must adapt their movements when the environment changes. The neural mechanisms of such adaptations are poorly understood, especially in respect to constraints that are unexpected and must be adapted to quickly. In this study, we […]

Horizontal slices of mouse retina expose horizontal cells and their properties

by Wallace B. Thoreson Abstract In most neurons, the post-synaptic response is constructed from a sum of individual quantal currents that each arise from release of a presynaptic vesicle. Characterizing the properties of quantal release events is essential for understanding how information about changing light levels transduced in photoreceptor outer segments is subsequently encoded for […]

mTORC1 and mTORC2 have largely distinct functions in Purkinje cells

by Nico Angliker, Michael Burri, Mariana Zaichuk, Jean-Marc Fritschy, Markus A. Rüegg Abstract The mammalian target of rapamycin (mTOR) is a key regulator of cellular growth that associates with other proteins to two multi-protein complexes, called mTORC1 and mTORC2. Dysregulation of mTORC1 signalling in brain is implicated in neuropathological conditions, such as autism spectrum or […]

The postcentral sulcal complex and the transverse postcentral sulcus and their relation to sensorimotor functional organization

by Veronika Zlatkina, Céline Amiez, Michael Petrides Abstract It has been demonstrated that the postcentral sulcus, which forms the posterior boundary of the sensorimotor region, is a complex of distinct sulcal segments. Although the general somatotopic arrangement in the human sensorimotor cortex is relatively well known, we do not know whether the different segments of […]

Pre-differentiation of mesenchymal stromal cells in combination with a microstructured nerve guide supports peripheral nerve regeneration in the rat sciatic nerve model

by Arne Hendrik Boecker, Sabien Geraldine Antonia Neerven, Juliane Scheffel, Julian Tank, Haktan Altinova, Katrin Seidensticker, Ronald Deumens, Rene Tolba, Joachim Weis, Gary Anthony Brook, Norbert Pallua, Ahmet Bozkurt Abstract Many bioartificial nerve guides have been investigated pre-clinically for their nerve regeneration supporting function, often in comparison to the autologous nerve transplantation, which is still […]

A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity

by Mia Apuschkin, Sara Stilling, Troels Rahbek-Clemmensen, Gunnar Sørensen, Guillaume Fortin, Freja Herborg Hansen, Jacob Eriksen, Louis-Eric Trudeau, Kristoffer Egerod, Ulrik Gether, Mattias Rickhag Abstract Midbrain dopaminergic (DAergic) neurons are heterogeneous and composed of functionally distinct cell populations projecting to the basal ganglia, prefrontal cortex and limbic system. Despite their functional significance, the midbrain population […]

Persistent alterations in active and passive electrical membrane properties of regenerated nerve fibers of man and mice

by Mihai Moldovan, Susana Alvarez, Mette R. Rosberg, Christian Krarup Abstract Excitability of regenerated fibers remains impaired due to changes in both passive cable properties and alterations in the voltage-dependent membrane function. We studied these abnormalities by mathematical modeling in human regenerated nerves and experimental studies in mice. In 3 adult male patients with surgically […]

Your ticket to independence: A guide to getting your first Principal Investigator position

by Ragnhildur Thóra Káradóttir, Johannes J. Letzkus, Manuel Mameli, Carlos Ribeiro Abstract The transition to scientific independence as a principal investigator (PI) can seem like a daunting and mysterious process to postdocs and students – something that many aspire to while at the same time wondering how to achieve this goal and what being a […]