Early View Articles articles

Effects of context-drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats

by David J. Rademacher, Nasya Mendoza-Elias, Gloria E. Meredith Abstract Context-drug learning produces structural and functional synaptic changes in the circuitry of the basolateral nucleus of the amygdala (BLA). However, how the synaptic changes translated to the neuronal targets was not established. Thus, in the present study, immunohistochemistry with a cell-specific marker and the stereological […]

Evidence for a role of corrective eye movements during gaze fixation in saccade planning

by Laura Pérez Zapata, María Solé Puig, Jose Antonio Aznar-Casanova, Hans Supèr Abstract In a three-dimensional (3D) world most saccades are made towards visual targets that are located at different distances. We previously demonstrated that gaze shifts within 3D space consist of two stages: a target saccade followed by a corrective saccade during gaze fixation […]

Gestational stress induces persistent depressive-like behavior and structural modifications within the postpartum nucleus accumbens

by Achikam Haim, Morgan Sherer, Benedetta Leuner Abstract Postpartum depression (PPD) is a common complication following childbirth experienced by one in every five new mothers. Pregnancy stress enhances vulnerability to PPD and has also been shown to increase depressive-like behavior in postpartum rats. Thus, gestational stress may be an important translational risk factor that can […]

Acute inhibition of a cortical motor area impairs vocal control in singing zebra finches

by Yoko Yazaki-Sugiyama, Shin Yanagihara, Patrick M. Fuller, Michael Lazarus Abstract Genetically targeted approaches that permit acute and reversible manipulation of neuronal circuit activity have enabled an unprecedented understanding of how discrete neuronal circuits control animal behavior. Zebra finch singing behavior has emerged as an excellent model for studying neuronal circuit mechanisms underlying the generation […]

Role of the anterior insular cortex in integrative causal signaling during multisensory auditory–visual attention

by Tianwen Chen, Lars Michels, Kaustubh Supekar, John Kochalka, Srikanth Ryali, Vinod Menon Abstract Coordinated attention to information from multiple senses is fundamental to our ability to respond to salient environmental events, yet little is known about brain network mechanisms that guide integration of information from multiple senses. Here we investigate dynamic causal mechanisms underlying […]

Stuttering as a trait or state – an ALE meta-analysis of neuroimaging studies

by Michel Belyk, Shelly Jo Kraft, Steven Brown Abstract Stuttering is a speech disorder characterised by repetitions, prolongations and blocks that disrupt the forward movement of speech. An earlier meta-analysis of brain imaging studies of stuttering (Brown et al., 2005) revealed a general trend towards rightward lateralization of brain activations and hyperactivity in the larynx motor […]

Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats

by Saskia W. Hel, Ellen V. S. Hessel, Ineke W. M. Bos, Sandra Mulder, Suzanne A. M. W. Verlinde, Pieter Eijsden, Pierre N. E. Graan Abstract Mesiotemporal sclerosis (MTS), the most frequent form of drug-resistant temporal lobe epilepsy, often develops after an initial precipitating injury affecting the immature brain. To analyse early processes in epileptogenesis […]

Unilateral medial frontal cortex lesions cause a cognitive decision-making deficit in rats

by Paula L. Croxson, Mark E. Walton, Erie D. Boorman, Matthew F. S. Rushworth, David M. Bannerman Abstract The medial frontal cortex (MFC) is critical for cost–benefit decision-making. Generally, cognitive and reward-based behaviour in rodents is not thought to be lateralised within the brain. In this study, however, we demonstrate that rats with unilateral MFC […]

α-Synuclein staging in the amygdala of a Parkinson's disease model: cell types involved

by Alicia Flores-Cuadrado, Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Carlos Rosa-Prieto, Alino Martinez-Marcos Abstract Lewy bodies (ubiquitin and α-synuclein aggregates) can be detected in brain areas in a predictable sequence of six neuropathological stages in Parkinson’s disease. Brainstem and olfactory structures are involved in stage 1, whereas the substantia nigra and amygdala are involved in stage 3, […]

Activity-dependent modulation of the axonal conduction of action potentials along rat hippocampal mossy fibers

by Kuniaki Chida, Kenya Kaneko, Satoshi Fujii, Yoshihiko Yamazaki Abstract The axonal conduction of action potentials in the nervous system is generally considered to be a stable signal for the relaying of information, and its dysfunction is involved in impairment of cognitive function. Recent evidence suggests that the conduction properties and excitability of axons are […]