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News Special Issues 

Special Issue -THE NEUROBIOLOGY OF AGING & ALZHEIMER’S DISEASE: WALKING DOWN THE SAME ROAD?

Understanding normal and pathological aging will benefit from considering multiple levels of analysis, ranging from complex neuronal circuits to the molecular mechanisms.  Reflecting this view, this Special Issue is organized around four themes: i) Global perturbation of neuronal circuits and networks; ii) Mechanisms of altered cell-cell communication; iii) Intracellular signaling mediating neural degeneration; and iv) Birth in death: saving neurons and rejuvenating the brain. The overall goal of this discussion has been to arrive at a clearer understanding of the mechanistic similarities and differences between normal and AD-type cognitive aging….

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News Special Issues 

Special Issue on the Dynamics of Neurological Disease

“There is a vast (and rapidly growing) amount of experimental and clinical data of the
nervous system at very diverse spatial scales of activity (e.g. from sub-cellular through to
 whole organ), with many neurological disorders characterised by oscillations in neural
activity across these disparate scales. Computer modelling and the development of
 associated mathematical theories provide us with a unique opportunity to integrate 
information from across these diverse scales of activity; leading to explanations of the 
potential mechanisms underlying the time-evolving dynamics and more importantly
allowing the development of new hypotheses regarding neural function…

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News Special Issues 

Special Feature: Development and Plasticity of Thalamocortical Systems

A new Special Feature of EJN focused on the development and plasticity of thalamocortical systems has now been published online.   In February 2011, scientists assembled in Arolla, a picturesque village in the Swiss Alps, to discuss aspects of thalamocortical development and function. In this special issue of European Journal of Neuroscience, we recapitulate some of the topics discussed at the meeting and argue that the years of glory may be back; with the ever-expanding availability of molecular approaches that enable cell-type-specific manipulation of cell identity and activity, the field…

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News Special Issues 

Special Issue: Beyond the Simple Reinforcement Learning Framework

This Special Issue of EJN entitled “Beyond Simple Reinforcement Learning: the Computational Neurobiology of Reward-Learning and Valuation” (edited by John O’Doherty) was published online on April 4, 2012 (EJN issue 35-7). Neural computational accounts of reward-learning have been dominated by the hypothesis that dopamine neurons behave like a reward-prediction error and thus facilitate reinforcement-learning in striatal target neurons. While this framework is consistent with a lot of behavioral and neural evidence, this theory fails to account for a number of behavioral and neurobiological observations. In this special issue of EJN…

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News Special Issues 

Special Issue: Molecular Mechanisms of Neuronal Differentiation

What are the precise molecular and cellular mechanisms that the human brain exploits to encode consciousness, identity and thought? This remains undoubtedly one of the greatest scientific challenges facing mankind. This Special Issue addresses with eminent precision the rules that dictate the structural and functional diversity of neurons as well as the molecular principles that integrate these cells into coherent and dynamic networks during development.

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