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Oxycodone evokes a greater increase in dopamine release in the nucleus accumbens than morphine

 

In this Featured Article of the month (October 2014), researchers measured rapid dopamine and other neurotransmitter release following intravenous infusion of morphine and oxycodone. They found that, although both opioids increased dopamine in the nucleus accumbens,  oxycodone evoked a significantly greater and longer increase in dopamine concentration, while morphine evoked a brief increase in dopamine and a surge in GABA. This study reveals previously unknown differences in opioid-induced neurotransmitter signaling.

Watch this Interview with Brandon Aragona, corresponding author of the related article.

Access full text: Rapid dopamine transmission within the nucleus accumbens: Dramatic difference between morphine and oxycodone delivery at http://onlinelibrary.wiley.com/doi/10.1111/ejn.12709/full

Access the Commentary by Dan P. Coveyand Joseph F. Cheer: Pick your poison: not all opioids are created equal in the eyes of dopamine at http://onlinelibrary.wiley.com/doi/10.1111/ejn.12726/full

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