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Review Article: The diverse roles and multiple forms of focal adhesion kinase in brain

Focal Adhesion Kinase, the main transducer of integrin signaling, deserves particular attention during brain development. FAK is found in various alternatively spliced forms and distributed in multiple subcellular compartments. FAK increases or decreases migration, participates in differentiation, and contributes to plasticity events. It is also linked to cell survival in cancer and apoptosis. This review focuses on the diversity of events involving brain-located forms of FAK. Read more

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